Defining and Validating Biomarkers
Imaging biomarkers are quantitative features that reflect biological processes and validation requires correlation with clinical outcomes reproducibility testing and multicenter validation to ensure generalizability
Clinical Applications and Trial Use
Biomarkers support oncology response assessment neurology progression monitoring and cardiology function evaluation and standardized acquisition and measurement conventions are essential for use in clinical trials
Regulatory and Implementation Pathways
Translating biomarkers into clinical practice involves regulatory validation demonstration of clinical utility and integration into reporting workflows and decision support to ensure they inform patient management reliably